Histiocyte-Rich Renal Epithelial Neoplasm: A Morphology Associated With Folliculin Mutations and Birt-Hogg-Dubé Syndrome.

Abstract excerpt

So-called hybrid oncocytic tumor (HOT) is the renal neoplasm most commonly associated with the germline folliculin ( FLCN ) mutations that define Birt-Hogg-Dubé syndrome. However, the spectrum of renal epithelial neoplasms associated with FLCN gene mutations has recently expanded to include neoplasms with somatic FLCN mutations and those with variant morphology. Some of these FLCN -mutated neoplasms overlap...

Topics

• Humans
• Birt-Hogg-Dube Syndrome
• Proto-Oncogene Proteins
• Kidney Neoplasms
• Tumor Suppressor Proteins