Article
Immunohistochemical characterization of renal tumors in patients with Birt-Hogg-Dubé syndrome.
Pathology international - 1 Mar 2015
Iribe Yasuhiro, Kuroda Naoto, Nagashima Yoji, Yao Masahiro, Tanaka Reiko, Gotoda Hiroko, Kawakami Fumi, Imamura Yoshiaki, Nakamura Yasushi, Ando Midori, Araki Akinobu, Matsushima Jun, Nakatani Yukio, Furuya Mitsuko
Abstract excerpt
Birt-Hogg-Dubé syndrome (BHD) is an autosomal dominant disorder associated with a germline mutation of folliculin (FLCN). The affected families are at a high risk for developing multiple renal cell carcinomas (RCC). Little is known about the immunostaining patterns of mutant FLCN-associated RCCs. We investigated 32 RCCs obtained from 17 BHD patients. The studied tumors included chromophobe RCCs (n = 15), hybrid...
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