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Spermatogonia: a unique stem cell orchestrating species-specific transition from pluripotency to sperm production

23 May 2025

Abstract excerpt

BACKGROUND: Male germline stem cells are relevant for stem cell researchers but also for andrologists as they are crucial for testis function and initiation/maintenance of spermatogenesis. They are also considered a target for fertility preservation in the male; e.g. germ cell transplantation or testicular grafting rely on spermatogonial stem cells (SSCs) and may soon become clinical tools to recover fertility....

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PMID: 40407420
DOI: 10.1093/humupd/dmaf010

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