Article

Ophthalmic imaging as a measure of cardiovascular and neurological health: a multi-omic analysis of deep-learning derived phenotypes

2025-08-06

Abstract excerpt

The eye is a recognised source of biomarkers for cardiovascular and neurodegenerative disease risk. Here, we characterise the breadth of these associations and identify biological axes that may mediate them. Using UK Biobank data, we developed a multi-omic analysis pipeline integrating physiological, radiomic, metabolomic, and genomic information. We trained adversarial autoencoders (Ret-AAE) to represent optical...

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Literature Corpus work: 43e068b3-5a06-56bf-b44b-ab778b8bc8d6
DOI: 10.1101/2025.08.04.25332962

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