Article
Automated AI labeling of optic nerve head enables insights into cross-ancestry glaucoma risk and genetic discovery in >280,000 images from UKB and CLSA.
American journal of human genetics - 1 Jul 2021
Han Xikun, Steven Kaiah, Qassim Ayub, Marshall Henry N, Bean Cameron, Tremeer Michael, An Jiyuan, Siggs Owen M, Gharahkhani Puya, Craig Jamie E, Hewitt Alex W, Trzaskowski Maciej, MacGregor Stuart
Abstract excerpt
Cupping of the optic nerve head, a highly heritable trait, is a hallmark of glaucomatous optic neuropathy. Two key parameters are vertical cup-to-disc ratio (VCDR) and vertical disc diameter (VDD). However, manual assessment often suffers from poor accuracy and is time intensive. Here, we show convolutional neural network models can accurately estimate VCDR and VDD for 282,100 images from both UK Biobank and an...
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