Article

FHL3 Contributes to EMT and Chemotherapy Resistance Through Inhibiting Ubiquitination of Slug and Activating TGFβ/Smad-Independent Pathways in Gastric Cancer

2020-10-09

Abstract excerpt

<h4>Background: </h4> Gastric cancer presents high risk of metastasis and chemotherapy resistance. Hence, the mechanistic understanding of the tumor metastasis and chemotherapy resistance is quietly important. <h4>Methods: </h4>: TCGA database and clinical samples are used for exploring the role of FHL3 in disease progression and prognosis. The roles of FHL3 in metastasis and chemotherapy resistance are explored i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 431a9611-3dd9-5244-9fa5-41d2fd0bec4f
DOI: 10.21203/rs.3.rs-87249/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

FHL3 Contributes to EMT and Chemotherapy Resistance Through Inhibiting Ubiquitination of Slug and Activating TGFβ/Smad-Independent Pathways in Gastric CancerDOI 10.21203/rs.3.rs-87249/v1Read

TGIF2-Induced HMGB3 Promotes Esophageal Squamous Cell Carcinoma Progression Through TGFβ SignalingSemantic proximity Read

Construction of epithelial-mesenchymal transition related miRNAs signatures as prognostic biomarkers in gastric cancer patientsSemantic proximity Read

SLUG is Enhanced by Chemotherapeutics and Functions to Promote Invasion and Metastasis by Directly Targeting MMP3 in Cervical CancerSemantic proximity Read

Construction of epithelial-mesenchymal transition related miRNAs signatures as prognostic biomarkers in gastric cancer patientsSemantic proximity Read

Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapySemantic proximity Read

RHOJ Induces Epithelial-to-Mesenchymal Transition by IL-6/STAT3 to Promote Invasion and Metastasis in Gastric CancerSemantic proximity Read

HUNK inhibits epithelial-mesenchymal transition of CRC via direct phosphorylation of GEF-H1 and activating RhoA/LIMK-1/CFL-1Semantic proximity Read

HOXA13 contributes to gastric carcinogenesis through DHRS2 interacting with MDM2 and confers 5‐FU resistance by a p53‐dependent pathwaySemantic proximity Read

Study on miR-144-3p targeting CDH11 to suppress malignant biological behaviors of gastric cancerSemantic proximity Read

Silencing MASTL Inhibits Cell Proliferation and Migration of Gastric Cancer MGC-803 Cells Via Suprressing AKT, mTOR, p38 Signal PathwaysSemantic proximity Read

Targeting 14-3-3ζ overcomes resistance to EGFR-TKI in lung adenocarcinoma via BMP2/Smad/ID-1 signalingSemantic proximity Read

Role of the epithelial-mesenchymal transition regulator Slug in primary human cancersSemantic proximity Read