Article

Packpred: Predicting the functional effect of missense mutations

2021-01-02

Abstract excerpt

1. Predicting the functional consequences of single point mutations has relevance to protein function annotation and to clinical analysis/diagnosis. We developed and tested Packpred that makes use of a multi-body clique statistical potential in combination with a depth dependent amino acid substitution matrix (FADHM) and positional Shannon Entropy to predict the functional consequences of point mutations in protei...

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Literature Corpus work: 429f395d-5587-550d-8eee-249bebbb4926
DOI: 10.1101/2020.12.30.424909

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