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Oxidative DNA Damage Drives Apoptotic Photoreceptor Loss in <i>NMNAT1</i> -Associated Inherited Retinal Degeneration: A Therapeutic Opportunity

2025-06-06

Abstract excerpt

Early-onset inherited retinal degenerations (IRDs), such as Leber congenital amaurosis (LCA) caused by pathogenic variants in the NMNAT1 gene, lead to severe vision loss in children. Despite its ubiquitous expression, reduced NMNAT1 function primarily affects photoreceptor cells (PRs) of the retina, yet the mechanisms underlying their heightened vulnerability remain incompletely understood. Here, we demonstrate...

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Literature Corpus work
42567cf3-0953-53c6-9d25-c8ff2d028435
DOI
10.1101/2025.06.05.658162
Open publication

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Oxidative DNA Damage Drives Apoptotic Photoreceptor Loss in <i>NMNAT1</i> -Associated Inherited Retinal Degeneration: A Therapeutic OpportunityDOI 10.1101/2025.06.05.658162
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