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Article

Oxidative DNA damage drives apoptotic photoreceptor loss in NMNAT1-associated inherited retinal degeneration: a therapeutic opportunity.

Cell death & disease - 2 Apr 2026

Zhang Hanmeng, Valestil Kevin, Butcher Rossano M, Pierce Eric A

Abstract excerpt

Early-onset inherited retinal degenerations (IRDs), such as Leber congenital amaurosis (LCA) caused by pathogenic variants in the NMNAT1 gene, lead to severe vision loss in children. Despite its ubiquitous expression, reduced NMNAT1 function primarily affects photoreceptor cells (PRs) of the retina, yet the mechanisms underlying their vulnerability remain incompletely understood. Here, we demonstrate that reduced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41922335
DOI: 10.1038/s41419-026-08680-7
PMCID: PMC13168578

Genes

NMNAT1
ERG
H2AX

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

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Oxidative DNA damage drives apoptotic photoreceptor loss in NMNAT1-associated inherited retinal degeneration: a therapeutic opportunity.PMID 41922335Read ↗

Oxidative DNA Damage Drives Apoptotic Photoreceptor Loss in <i>NMNAT1</i> -Associated Inherited Retinal Degeneration: A Therapeutic OpportunitySemantic proximity Read ↗

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Expression of NMNAT1 in the Photoreceptors is Sufficient to Prevent <i>NMNAT1</i> -Associated DiseaseSemantic proximity Read ↗

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