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Assessing the effects of fluids and antibiotics in an acute murine model of sepsis: study protocol for the National Preclinical Sepsis Platform-01 (NPSP-01) Study

2025-05-01

Abstract excerpt

<h4>Background: </h4> Sepsis remains a leading cause of mortality in critical care. Despite extensive preclinical research on sepsis pathophysiology, the development of effective therapies has been largely unsuccessful. Key obstacles include limited construct validity of animal models, insufficient methodological rigor and the lack of collaborative frameworks akin to clinical trials. These issues plague not only s...

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Literature Corpus work
41721328-3b8e-5d91-a6e7-76cf281aebfc
DOI
10.12688/f1000research.163800.1
Open publication

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Assessing the effects of fluids and antibiotics in an acute murine model of sepsis: study protocol for the National Preclinical Sepsis Platform-01 (NPSP-01) StudyDOI 10.12688/f1000research.163800.1
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