Article

Insulin receptor substrate 2 (IRS2) confers resistance to PI3K pathway inhibition in <i>PIK3CA</i> mutant breast cancer

2026-04-28

Abstract excerpt

Activating mutations in PI3K are one of the most frequent mutations in breast cancer and are associated with worse patient outcomes in many breast cancer subtypes. Despite intense interest, cancer treatments that target the PI3K pathway have been only modestly effective due to intrinsic and acquired resistance mechanisms which reactivate PI3K signaling. Here, we characterize a feedback mechanism by which PI3K path...

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Literature Corpus work: 4163110b-7036-5a81-a239-054567c430c3
DOI: 10.64898/2026.04.24.720709

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