Circulating mitochondrial DNA levels are associated with early diagnosis and prognosis in patients with sepsis

Abstract excerpt

To the Editor: Both pathogen-associated molecular patterns and damage-associated molecular patterns (DAMPs) are known to enhance levels of inflammation and tissue injury during sepsis. Mitochondria are a major source of DAMPs because they release mitochondrial (mt) DNA fragments during sepsis. Similar to bacterial DNA, circulating mtDNA can activate signaling pathways and promulgate inflammation. Previously,...

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