Article

Normalization of enzyme expression and activity regulating vitamin A metabolism increases RAR-beta expression and reduces cellular migration and proliferation in diseases caused by tuberous sclerosis gene mutations

2020-12-03

Abstract excerpt

<title>Abstract</title> <p>Background Mutation in a tuberous sclerosis gene (TSC1 or 2) leads to continuous activation of the mammalian target of rapamycin (mTOR). mTOR activation alters cellular including vitamin A metabolism and retinoic acid receptor beta (RARβ) expression. The goal of the present study was to investigate the molecular connection between vitamin A metabolism and TSC mutation. We also aimed to...

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Literature Corpus work: 40f77ecf-33b4-510f-b383-36aa73ccfa62
DOI: 10.21203/rs.3.rs-41687/v2

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Normalization of enzyme expression and activity regulating vitamin A metabolism increases RAR-beta expression and reduces cellular migration and proliferation in diseases caused by tuberous sclerosis gene mutationsDOI 10.21203/rs.3.rs-41687/v2Read

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