Back to search

Article

A Continuously Oxygenated Macroencapsulation System Enables High-Density Packing and Delivery of Insulin-Secreting Cells

2025-04-24

Abstract excerpt

The encapsulation of insulin-secreting cells within immuno-protective systems holds significant promise for curative treatment of type 1 diabetes without immunosuppression. A major challenge, however, remains the inadequate oxygen tension within the encapsulation systems, which compromises the survival and function of encapsulated cells and necessitates low packing density and impractically large systems to delive...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
40bf0db1-78fc-563b-97c1-6420d293e608
DOI
10.1101/2025.04.21.649806
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Continuously Oxygenated Macroencapsulation System Enables High-Density Packing and Delivery of Insulin-Secreting CellsDOI 10.1101/2025.04.21.649806
Optimization of An O2-Balanced Bioartificial Pancreas for Type 1 Diabetes Using Statistical Design of Experiment.Semantic proximity
Improved phenotype of rat islets in a macrocapsule by co-encapsulation with cross-linked Hb.Semantic proximity
Transplantation of Macroencapsulated Insulin-Producing Cells.Semantic proximity
Organ Chips with integrated multifunctional sensors enable continuous metabolic monitoring at controlled oxygen levelsSemantic proximity
Towards 3D-Bioprinting of an Endocrine Pancreas: A Building-Block Concept for Bioartificial Insulin-Secreting TissueSemantic proximity
Clinical-grade cryopreservation unlocks transplant-ready human pancreatic and stem cell–derived islets for diabetes therapySemantic proximity
Encapsulation of Human Islets in Novel Inhomogeneous Alginate-Ca<sup>2+</sup>/Ba<sup>2+</sup>Microbeads:<i>In Vitro</i>and<i>In Vivo</i>FunctionSemantic proximity
Long-term efficacy of encapsulated xenogeneic islet transplantation: Impact of encapsulation techniques and donor genetic traits.Semantic proximity
Adipose-derived stromal cells preserve pancreatic islet function in a transplantable 3D bioprinted scaffoldSemantic proximity
Encapsulated, genetically engineered cells, secreting glucagon-like peptide-1 for the treatment of non-insulin-dependent diabetes mellitus.Semantic proximity
Establishment of physiologically relevant oxygen gradients in microfluidic organ chipsSemantic proximity
Sustained Oxygenation Accelerates Diabetic Wound Healing by Simultaneously Promoting Epithelialization and Angiogenesis, and Decreasing Tissue InflammationSemantic proximity
Select a neighboring publication to make it the new centre.