Article

A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity

2025-04-18

Abstract excerpt

The RNA-binding protein IGF2BP3 is an oncofetal protein overexpressed in B-acute lymphoblastic leukemia and is critical for leukemogenesis in experimental models. With cancer-specific expression, functional dispensability for normal development, and an unleveraged pro-oncogenic function in mRNA homeostasis, IGF2BP3 represents an excellent target. With no small molecule inhibitors of IGF2BP3 in clinical use, we und...

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Literature Corpus work: 40a841d5-3bba-52f4-97fc-e2e642112afb
DOI: 10.1101/2025.04.14.648780

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