Article

SQSTM1/p62 is a prognostic molecular marker and potential therapeutic target for pancreatic neuroendocrine tumours

2023-08-10

Abstract excerpt

<title>Abstract</title> <p>Background There have been few studies on the role of autophagy in pancreatic neuroendocrine tumours (PNETs). SQSTM1/p62 (also called Sequestosome 1) is a potential autophagy regulator, and its biological roles and clinical significance in PNETs remain poorly understood. Purpose The purpose of this study was to evaluate the clinical significance of SQSTM1/p62 in human PNET specimens a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4098c7c3-1df6-5197-ab49-5a928db10365
DOI: 10.21203/rs.3.rs-3217620/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SQSTM1/p62 is a prognostic molecular marker and potential therapeutic target for pancreatic neuroendocrine tumoursDOI 10.21203/rs.3.rs-3217620/v1Read

p62/SQSTM1 Accumulation Defines an Epithelial-Mesenchymal Transition (EMT)/Twist1-Associated Infiltrative Phenotype in Pancreatic Neuroendocrine Tumors.Semantic proximity Read

Cytoplasmic SQSTM1/ P62 Accumulation Predicates a Poor Prognosis in Patients with Malignant TumorSemantic proximity Read

Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review)Semantic proximity Read

Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomasSemantic proximity Read

Autophagic Regulation of p62 is Critical for Cancer TherapySemantic proximity Read

STK33 Promotes the Growth and Progression of Human Pancreatic Neuroendocrine Tumour via Activation of the PI3K/AKT/mTOR PathwaySemantic proximity Read

Prognostic relevance of proliferation-related miRNAs in pancreatic neuroendocrine neoplasmsSemantic proximity Read

Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabineSemantic proximity Read

Simvastatin protects pancreatic cancer cells by promoting mitochondrial autophagy through TFEBSemantic proximity Read

Effect of Small Nuclear RNA 64 (SNORA64) on Apoptosis Regulator Genes in Pancreatic Cancer in VitroSemantic proximity Read

Decreased miR- 31 Suppress Cell Migration and Proliferation By Targeting Syncytin-1 in Pancreatic CarcinomaSemantic proximity Read

Linc00462 promotes pancreatic cancer invasiveness through the miR-665/TGFBR1-TGFBR2/SMAD2/3 pathway.Semantic proximity Read