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The Histone Demethylase LSD1/ZNF217/CoREST Complex is a Major Restriction Factor of Epstein-Barr Virus Lytic Reactivation

2025-01-13

Abstract excerpt

<title>Abstract</title> <p>Epstein-Barr virus (EBV) contributes to ~1.5% of human cancers, including lymphomas, gastric and nasopharyngeal carcinomas. In most of these, nearly 80 viral lytic genes are silenced by incompletely understood epigenetic mechanisms, precluding use of antiviral agents such as ganciclovir to treat the 200,000 EBV-associated cancers/year. To identify host factors critical for EBV latency,...

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Literature Corpus work
4017137e-b7cc-541a-92c7-953afef1b8e8
DOI
10.21203/rs.3.rs-5649616/v1
Open publication

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