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Article

The nuclear lamina and inherited disease.

Trends in cell biology - 1 Dec 2002

Worman Howard J, Courvalin Jean-Claude

Abstract excerpt

Inherited disorders of the nuclear lamina present some of the most intriguing puzzles in cell biology. Mutations in lamin A and lamin C - nuclear intermediate filament proteins that are expressed in nearly all somatic cells - cause tissue-specific diseases that affect striated muscle, adipose tissue and peripheral nerve or skeletal development. Recent studies provide clues about how different mutations in these...

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PMID: 12495848
DOI: 10.1016/s0962-8924(02)02401-7

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