Article

Caffeine consumption and interaction with ADORA2A, CYP1A2 and NOS1 variants do not influence age at onset of Machado-Joseph disease

2024-05-02

Abstract excerpt

<title>Abstract</title> <p>Background The age at onset (AO) of Machado-Joseph disease (SCA3/MJD), a disorder due to an expanded CAG repeat (CAGexp) in <italic>ATXN3</italic>, is quite variable and the role of environmental factors is still unknown. Caffeine was associated with protective effects against other neurodegenerative diseases, and in transgenic SCA3/MJD mouse models. We aimed to evaluate whether caffei...

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Literature Corpus work: 3fed0243-35bb-555e-b562-d1f8846264b2
DOI: 10.21203/rs.3.rs-4325198/v1

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