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Article

The role of apolipoprotein E as a risk factor for an earlier age at onset for Machado-Joseph disease is doubtful.

PloS one - 1 Jan 2014

Zhou Qi, Ni Wang, Dong Yi, Wang Ning, Gan Shi-Rui, Wu Zhi-Ying

Abstract excerpt

Machado-Joseph disease (MJD) is an inherited neurodegenerative disease caused by an expanded CAG repeat in the ATXN3 gene. Although the principal genetic determinant of the age at onset (AAO) is the length of the expanded CAG repeat, the additional genetic contribution of MJD toward the AAO has mostly not yet been clarified. It was recently suggested in two independent studies that apolipoprotein E (APOE) might...

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Source

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Identifiers

PMID: 25369462
DOI: 10.1371/journal.pone.0111356
PMCID: PMC4219713

Genes

APOE
ATXN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The role of apolipoprotein E as a risk factor for an earlier age at onset for Machado-Joseph disease is doubtful.PMID 25369462Read ↗

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