Article

Systematic interrogation of diverse Omic data reveals interpretable, robust, and generalizable transcriptomic features of clinically successful therapeutic targets

2017-11-16

Abstract excerpt

<h4>ABSTRACT</h4> Target selection is the first and pivotal step in drug discovery. An incorrect choice may not manifest itself for many years after hundreds of millions of research dollars have been spent. We collected a set of 332 targets that succeeded or failed in phase III clinical trials, and explored whether Omic features describing the target genes could predict clinical success. We obtained features from...

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Literature Corpus work: 3fd00b1d-c7b8-55a0-9231-06e713dba0e4
DOI: 10.1101/220848

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