Article

Integrating bulk and single-cell RNA sequencing reveals<i>SH3D21</i>promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway

2024-04-16

Abstract excerpt

As a novel genetic biomarker, the potential role of SH3D21 in hepatocellular carcinoma remains unclear. Here, we decipher the expression and function of SH3D21 in human hepatocellular carcinoma. The expression level and clinical significance of SH3D21 in hepatocellular carcinoma patients, the relationship between SH3D21 and the features of tumor microenvironment (TME) and role of SH3D21 in promoting hepatocellular...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3fc27b0b-35b1-555c-b31b-f5d81e8d33da
DOI: 10.1101/2024.04.14.24305789

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrating bulk and single-cell RNA sequencing reveals<i>SH3D21</i>promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathwayDOI 10.1101/2024.04.14.24305789Read

Deciphering the heterogeneous niche in the tumor progression of hepatocellular carcinoma: a Spatial single-cell landscape and multi-omics atlas analysisSemantic proximity Read

PDCL3 is a Novel Oncogenic Indicator in Hepatocellular Carcinoma using Comprehensive Bioinformatics Analysis and in vitro ValidationSemantic proximity Read

Single-Cell RNA Sequencing Combined with Single-Cell Genome-Wide Association Study Identifies SF3B4 as a hub Gene in Hepatocellular Carcinoma ProgressionSemantic proximity Read

Clinical and Prognostic Value of PPIA, SQSTM1, and CCL20 in Hepatocellular Carcinoma Patients by Single-Cell Transcriptome AnalysisSemantic proximity Read

KLHL21, a novel gene that contributes to the progression of hepatocellular carcinomaSemantic proximity Read

Construction and validation of somatic mutation-derived LncRNA signatures of genomic instability to predict prognosis of hepatocellular carcinomaSemantic proximity Read

STAT3 regulates the migration and invasion of a stem-like subpopulation through microRNA-21 and multiple targets in hepatocellular carcinomaSemantic proximity Read

SPC25 promotes proliferation and stemness of hepatocellular carcinoma cells via the DNA-PK/AKT/Notch1 signaling pathwaySemantic proximity Read

Genomic and the tumor microenvironment heterogeneity in multifocal hepatocellular carcinomaSemantic proximity Read

Pan-Cancer Analysis Identifies CCDC51 as a Potential Biomarker for Liver Hepatocellular CarcinomaSemantic proximity Read

CircCOPA promotes hepatocellular carcinoma progression through the HNRNPD/SPRED2 axis-mediated activation of ERK/MAPK signaling pathwaySemantic proximity Read

CircSOD2 induced epigenetic alteration drives hepatocellular carcinoma progression through activating JAK2/STAT3 signaling pathwaySemantic proximity Read