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Robust SARS-CoV-2 Infection in Nasal Turbinate Despite Systemic Neutralizing Antibody

2020-10-13

Abstract excerpt

SARS-CoV-2 is characterized by a burst in upper-respiratory portal for high transmissibility. To determine human neutralizing antibodies (HuNAbs) for entry protection, we generated HuNAbs that bind to conformational determinants of viral receptor binding domain (RBD). HuNAb ZDY20 prevented pseudovirus and live virus entry with IC 90 values of 1.24 µg/ml and 1 µg/ml, respectively, by competing with human cellula...

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Literature Corpus work
3f8f5298-596d-538d-8ac7-088939647010
DOI
10.2139/ssrn.3699794
Open publication

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Robust SARS-CoV-2 Infection in Nasal Turbinate Despite Systemic Neutralizing AntibodyDOI 10.2139/ssrn.3699794
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