Article

An investigation of genetic and epigenetic factors in the regulation of gene expression in schizophrenia : insights into pathways involved in pathogenesis

2012-01-01

Abstract excerpt

Schizophrenia is a common psychiatric disorder with a complex aetiology that has a strong genetic component as well as a major contribution from non-genetic factors. Whilst GWAS studies have not yielded substantial evidence of DNA variants linked to schizophrenia, microarray expression studies, which reflect both genetic and environmental factors, have provided evidence of candidate genes whose expression changes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3f0ffb7b-a104-5b5f-bd13-60eac7e4233b
DOI: 10.25560/9205

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An investigation of genetic and epigenetic factors in the regulation of gene expression in schizophrenia : insights into pathways involved in pathogenesisDOI 10.25560/9205Read

Finding the needle in the haystack: a review of microarray gene expression research into schizophrenia.Semantic proximity Read

From Linkage Studies to Epigenetics: What We Know and What We Need to Know in the Neurobiology of SchizophreniaSemantic proximity Read

Recent genetic findings in schizophrenia and their therapeutic relevance.Semantic proximity Read

Epigenetics factors in schizophrenia: future directions for etiologic and therapeutic study approachesSemantic proximity Read

DNA Methylation in Schizophrenia.Semantic proximity Read

Use of the epigenetic toolbox to contextualize common variants associated with schizophrenia risk .Semantic proximity Read

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insightsSemantic proximity Read

Alteration of DNA Methylation and Epigenetic Scores Associated With Features of Schizophrenia and Common Variant Genetic RiskSemantic proximity Read

Transcriptome Sequencing Revealed Significant Alteration of Cortical Promoter Usage and Splicing in SchizophreniaSemantic proximity Read

Wnt receptor gene FZD1 was associated with schizophrenia in genome-wide SNP analysis of the Australian Schizophrenia Research Bank cohort.Semantic proximity Read

Neuroepigenetics of Schizophrenia.Semantic proximity Read

A Transcriptome Wide Association Study implicates specific pre- and post-synaptic abnormalities in SchizophreniaSemantic proximity Read