Article

Quantitative Phenotype Scan Statistic (QPSS) reveals rare variant associations with Alzheimer’s disease endophenotypes

2020-05-19

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Current sequencing technologies have provided for a more comprehensive genome-wide assessment and have increased genotyping accuracy of rare variants. Scan statistic approaches have previously been adapted to genetic sequencing data. Unlike currently-employed association tests, scan-statistic-based approaches can both localize clusters of disease-related variant...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3ecd824a-c90a-59f6-b719-2759b6153227
DOI: 10.21203/rs.2.20987/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Quantitative Phenotype Scan Statistic (QPSS) reveals rare variant associations with Alzheimer’s disease endophenotypesDOI 10.21203/rs.2.20987/v2Read

Quantitative phenotype scan statistic (QPSS) reveals rare variant associations with Alzheimer's disease endophenotypes.Semantic proximity Read

Empirical Bayes scan statistics for detecting clusters of disease risk variants in genetic studies.Semantic proximity Read

Beyond guilty by association at scale: searching for causal variants on the basis of genome-wide summary statisticsSemantic proximity Read

Detecting local genetic correlations with scan statistics.Semantic proximity Read

Summary statistics knockoff inference empowers identification of putative causal variants in genome-wide association studiesSemantic proximity Read

Identifying genetic risk variants associated with brain volumetric phenotypes via K-sample Ball Divergence method.Semantic proximity Read

Identifying single-nucleotide polymorphisms (SNPs) intersecting Alzheimer’s disease pathology and end-of-life traits using genomic informational field theory (GIFT)Semantic proximity Read

The exhaustive genomic scan approach, with an application to rare-variant association analysis.Semantic proximity Read

Scan statistics to scan markers for susceptibility genes.Semantic proximity Read

Detecting Local Genetic Correlations with Scan StatisticsSemantic proximity Read

Optimized phenotype definitions boost GWAS powerSemantic proximity Read

An Association Test of the Spatial Distribution of Rare Missense Variants within Protein Structures Improves Statistical Power of Sequencing StudiesSemantic proximity Read