Article

Pharmacogenetic Role of the Synaptosomal-Associated Protein 25 Gene in Clinical Response to Methylphenidate Among Turkish Pediatric ADHD Cohort

2026-05-25

Abstract excerpt

<title>Abstract</title> Background Methylphenidate (MPH) is a first-line treatment for attention-deficit/hyperactivity disorder (ADHD). MPH blocks dopamine and norepinephrine transporters, increasing synaptic catecholamine levels. Neurotransmitter release depends on presynaptic vesicle docking and fusion mediated by Synaptosomal-Associated Protein, 25 kDa (SNAP-25), a Target Soluble NSF Attachment Protein R...

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Literature Corpus work: 3e3c4cf3-09cc-59b0-880f-9eaf948be64c
DOI: 10.21203/rs.3.rs-9641413/v1

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