Article

SMN deficiency disrupts hepatic mitochondrial iron homeostasis and NRF2-dependent redox control in spinal muscular atrophy

2026-01-09

Abstract excerpt

Spinal muscular atrophy (SMA), classically defined as a motor neuron disorder caused by deficiency of the survival motor neuron (SMN) protein, is increasingly recognized as a multi-system disease. Among peripheral organs, the liver, essential for metabolic regulation and xenobiotic processing, remains underexplored despite growing evidence of dysfunction. Defining hepatic contributions may be critical for understa...

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Literature Corpus work: 3e34e04e-79d8-5219-9fdf-4e0cfdad0647
DOI: 10.64898/2026.01.08.698518

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