Article

Cardiac defects in spinal muscular atrophy and the role of SMN in cardiomyocyte homeostasis

2026-03-24

Abstract excerpt

Spinal muscular atrophy (SMA) is characterized by motor neuron degeneration caused by deficiency of the survival motor neuron (SMN) protein. However, evidence increasingly supports broader systemic involvement. This study aimed to examine cardiac pathology in SMA patients and to investigate how reduced SMN levels impact cardiomyocyte homeostasis. We analyzed postmortem data from 14 SMA type I patients from the pre...

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Literature Corpus work: 2f760866-552c-5712-99f6-5b4c2343021e
DOI: 10.64898/2026.03.20.713246

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