Article

A conserved immune dysregulation is associated with infection severity, risk factors prior to infection, and treatment response

2025-04-22

Abstract excerpt

Older age, being male, obesity, smoking, and comorbidities (e.g., diabetes, asthma) are associated with the increased risk for severe infections. We hypothesized that there is a conserved common immune dysregulation across these risk factors. We integrated single cell and bulk transcriptomic data and proteomic data from 12,026 blood samples across 68 cohorts to test this hypothesis. We found that our previously de...

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Literature Corpus work: 3d97cf3e-1360-5dcd-a061-f13e30fb8439
DOI: 10.1101/2025.04.18.649544

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