Article

3-Phenylpropionic acid, a microbiota-derived polyphenol metabolite linked to hippuric acid, ameliorates colitis as a colon-enriched PPAR-γ agonist

2025-11-26

Abstract excerpt

Polyphenols are promising therapeutics for Crohn’s disease (CD), yet their bioavailability is largely dependent on the gut microbiome. The bioactive metabolites, metabolic pathways, and anti-inflammatory mechanisms underlying their effects remain poorly defined. We identified hippuric acid (HIPA) as a biomarker of polyphenol–microbiome interaction. HIPA is a meta-organismal metabolite produced through a cross-orga...

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Literature Corpus work: 3d6618f4-3706-5edc-8f9d-3e747a5ec862
DOI: 10.1101/2025.11.25.690607

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