Article

Overcoming blinding confounds in psychedelic randomized controlled trials using biomarker driven causal mediation analysis

2023-06-13

Abstract excerpt

<p>There is great interest in the use of psychedelic-assisted therapies to treat a range of mental health conditions and initial randomized controlled trials (RCTs) trials have generated positive results. However, the effect sizes reported in psychedelic RCTs are likely inflated due to expectancy effects due to the de-blinding of both participants and study personnel to treatment allocation caused by the distincti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3d1ea21f-d700-594a-94cc-7fa820f3758e
DOI: 10.31234/osf.io/d52ay

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Overcoming blinding confounds in psychedelic randomized controlled trials using biomarker driven causal mediation analysisDOI 10.31234/osf.io/d52ayRead

Commentary on methods for addressing functional unblinding and mechanistic uncertainty in clinical trials of psychedelic-assisted treatmentsSemantic proximity Read

Blinding and Expectancy Confounds in Psychedelic Randomised Controlled TrialsSemantic proximity Read

MR-DoC2: Bidirectional Causal Modeling with Instrumental Variables and Data from Relatives.Semantic proximity Read

History repeating: A roadmap to address common problems in psychedelic scienceSemantic proximity Read

Pharmacoepidemiology research: Drug therapy and drug safety in mental healthSemantic proximity Read

Systematic comparison of Mendelian randomization studies and randomized controlled trials using electronic databasesSemantic proximity Read

Separating Biological and Choice Effects in Randomized Trials: Completing Causal Inference with β-IdentificationSemantic proximity Read

A Retrospective Study to Determine the Impact of Psychedelic Therapy for Dimensional Measures of Wellness: A Quantitative AnalysisSemantic proximity Read

The Reporting of Setting in Psychedelic Clinical Trials (ReSPCT) Guidelines: An international Delphi consensus studySemantic proximity Read

A Retrospective Study to Determine the Impact of Psychedelic Therapy for Dimensional Measures of Wellness: A Qualitative Analysis of Response DataSemantic proximity Read

Triangulating Instrumental Variable, confounder adjustment and difference-in-difference methods for comparative effectiveness research in observational dataSemantic proximity Read