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Commentary on methods for addressing functional unblinding and mechanistic uncertainty in clinical trials of psychedelic-assisted treatments

2025-09-15

Abstract excerpt

<p>Purpose of Review: This commentary summarizes how the intense and distinctive subjective effects of psychedelics complicate tests of the efficacy and mechanisms of action (MOAs) of psychedelic-assisted treatments (PATs) for mental-health conditions. Specifically, we discuss a) how estimates of PAT efficacy are confounded under functional unblinding and b) uncertainty surrounding whether subjective or neurobiolo...

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Literature Corpus work
1f6fe58c-8263-56f7-9283-4e0259736310
DOI
10.31234/osf.io/8dtuw_v2
Open publication

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Commentary on methods for addressing functional unblinding and mechanistic uncertainty in clinical trials of psychedelic-assisted treatmentsDOI 10.31234/osf.io/8dtuw_v2
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