Article

The PfAP2-HS transcription factor protects malaria parasites from febrile temperatures

2021-03-15

Abstract excerpt

Periodic fever is the most characteristic clinical feature of human malaria 1-3 , but how parasites survive febrile episodes is not known. While Plasmodium spp. genomes encode a full complement of chaperones 4 , they lack an ortholog of the conserved transcription factor HSF1, which in most eukaryotes activates the expression of key chaperones upon heat shock (HS) 5-8 . Here we identified PfAP2-HS, a transcrip...

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Literature Corpus work: 3cd78776-561d-5234-afe5-5e557241b7c2
DOI: 10.1101/2021.03.15.435375

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