Article

Detecting somatic variants in purified brain DNA obtained from surgically implanted depth electrodes in epilepsy

2024-07-10

Abstract excerpt

Somatic variants causing epilepsy are challenging to detect as they are only present in a subset of brain cells (e.g., mosaic) resulting in low variant allele frequencies. Traditional methods that rely on surgically resected brain tissue are limited to patients undergoing brain surgery. We developed an improved protocol to detect somatic variants using DNA from stereo- electroencephalography (SEEG) depth electrode...

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Literature Corpus work: 1c288159-f684-5a68-ba26-28eb446e7d35
DOI: 10.1101/2024.07.08.24310005

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