Article

Regulation of Lysosome-Associated Membrane Protein 3 (LAMP3) in Lung Epithelial Cells by Coronaviruses (SARS-CoV-1/2) and Type I Interferon Signaling

2021-04-28

Abstract excerpt

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is a major risk factor for mortality and morbidity in critical care hospitals around the world. Lung epithelial type II cells play a major role in several physiological processes, including recognition and clearance of respiratory viruses as well as repair of lung injury in response to environmental toxicants. Gene expression profiling of lung...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3c64e420-3301-5880-a0c6-dfd7659aa75c
DOI: 10.1101/2021.04.28.441840

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Regulation of Lysosome-Associated Membrane Protein 3 (LAMP3) in Lung Epithelial Cells by Coronaviruses (SARS-CoV-1/2) and Type I Interferon SignalingDOI 10.1101/2021.04.28.441840Read

Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 InfectionSemantic proximity Read

Autophagy‐linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS‐CoV‐2 entry into human cellsSemantic proximity Read

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial CellsSemantic proximity Read

ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egressSemantic proximity Read

TLR3 and TLR7 RNA Sensor Activation during SARS-CoV-2 InfectionSemantic proximity Read

SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell deathSemantic proximity Read

Quantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-CoV-2 innate immune evasionSemantic proximity Read

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial CellsSemantic proximity Read

Selective autophagy controls the stability of transcription factor IRF3 to balance type I interferon production and immune suppressionSemantic proximity Read

Coxsackievirus B3 Activates Macrophages Independently of CAR-Mediated Viral EntrySemantic proximity Read

SARS-CoV-2 Triggers an MDA-5-Dependent Interferon Response Which Is Unable To Control Replication in Lung Epithelial CellsSemantic proximity Read