Article

The Impact of Scaling up Dolutegravir on Antiretroviral Resistance in South Africa

2019-10-29

Abstract excerpt

<h4>Background</h4> Rising resistance of HIV-1 to non-nucleoside reverse transcriptase inhibitors (NNRTIs) threatens the success of the global scale-up of antiretroviral therapy (ART). The switch to WHO-recommended dolutegravir (DTG)-based regimens could reduce this threat due to DTG’s high genetic barrier to resistance. We used mathematical modelling to examine the impact of the scale-up of DTG-based ART on NNRTI...

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Literature Corpus work: 3b842618-4f20-55f2-93d6-c2709df8e01c
DOI: 10.1101/19010132

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