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Article

HIV transmission dynamics and population-wide drug resistance in rural South Africa.

Nature communications - 29 Apr 2024

Kemp Steven A, Kamelian Kimia, Cuadros Diego F, Cheng Mark T K, Okango Elphas, Hanekom Willem, Ndung'u Thumbi, Pillay Deenan, Bonsall David, Wong Emily B, Tanser Frank, Siedner Mark J, Gupta Ravindra K

Abstract excerpt

Despite expanded antiretroviral therapy (ART) in South Africa, HIV-1 transmission persists. Integrase strand transfer inhibitors (INSTI) and long-acting injectables offer potential for superior viral suppression, but pre-existing drug resistance could threaten their effectiveness. In a community-based study in rural KwaZulu-Natal, prior to widespread INSTI usage, we enroled 18,025 individuals to characterise...

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Share to Anti-HIV Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38684655
DOI: 10.1038/s41467-024-47254-z
PMCID: PMC11059351

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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