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Impact of scaling up dolutegravir on antiretroviral resistance in South Africa: A modeling study

14 Dec 2020

Abstract excerpt

BACKGROUND: Rising resistance of HIV-1 to non-nucleoside reverse transcriptase inhibitors (NNRTIs) threatens the success of the global scale-up of antiretroviral therapy (ART). The switch to WHO-recommended dolutegravir (DTG)-based regimens could reduce this threat due to DTG's high genetic barrier to resistance. We used mathematical modeling to predict the impact of the scale-up of DTG-based ART on NNRTI...

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PMID: 33315863
DOI: 10.1371/journal.pmed.1003397

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