Implications of gen(om)e duplications on the expansion and evolution of the GPCR signalling pathway

Abstract excerpt

Gene and genome duplications are important evolutionary events associated with the emergence of gene families and novel biological functions. G protein-coupled receptors (GPCRs) constitute the largest family of membrane proteins, and their associated signalling pathways control crucial physiological functions such as neurotransmission, endocrine activity, and immunity. However, the duplication history of the entir...

Topics

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• Dosage Compensation, Genetic
• Evolution, Molecular
• Gene Dosage
• Gene Duplication
• Gene Expression Regulation, Developmental
• Genome, Human
• Models, Biological
• Receptor Mechanisms and Signaling

Identifiers and source

Literature Corpus work

c82e3a40-07bf-5953-bada-0377c2fd7f7a

DOI

10.1101/2024.11.25.625254