Article

Transcriptomic interplay between <i>Acinetobacter baumannii</i> , human macrophage and polymyxin

2024-01-23

Abstract excerpt

<h4>ABSTRACT</h4> Optimization of antibiotic therapy has been hindered by our dearth of understanding on the mechanism of the host-pathogen-drug interactions. Here, we employed dual RNA-sequencing to examine transcriptomic perturbations in response to polymyxin B in a co-culture infection model of Acinetobacter baumannii and human macrophages. Our findings revealed that polymyxin B treatment induced significant...

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Literature Corpus work: 779b80dc-b170-5ab5-a818-928127ddb7a7
DOI: 10.1101/2024.01.23.576770

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