Article
The ArcA regulon and oxidative stress resistance in Haemophilus influenzae.
Molecular microbiology - 1 Jun 2007
Wong Sandy M S, Alugupalli Kishore R, Ram Sanjay, Akerley Brian J
Abstract excerpt
Haemophilus influenzae transits between niches within the human host that are predicted to differ in oxygen levels. The ArcAB two-component signal transduction system controls gene expression in response to respiratory conditions of growth and has been implicated in bacterial pathogenesis, yet the mechanism is not understood. We undertook a genome-scale study to identify genes of the H. influenzae ArcA regulon....
Topics
- Gene Deletion
- Gene Expression Profiling
- Haemophilus influenzae
- Hydrogen Peroxide
- Mutation
- Oxidants
- Oxidative Stress
- Plasmids
- Regulon