Article

The Energy-Deficit Hypothesis of Autism: Linking Parental TNF-α-Mediated Diseases to Offspring Autism Risk via Mitochondrial Dysfunction

2025-12-31

Abstract excerpt

<h4>Background: </h4> Autism spectrum disorder (ASD) affects approximately 1-2% of children worldwide, yet its etiology remains incompletely understood. Emerging evidence suggests that parental autoimmune diseases significantly increase offspring autism risk, with psoriasis (OR 1.59), type 1 diabetes (OR 1.49-2.36), and rheumatoid arthritis (OR 1.51) showing particularly strong associations. Hypothesis: I propose...

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Literature Corpus work: 3b3389c0-d2b7-5c9e-af53-74410618fba1
DOI: 10.20944/preprints202512.2808.v1

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