Article

Indolo[2,3-b]quinoline derivatives as novel promising antitumor agents

2016-01-21

Abstract excerpt

In the search for novel antineoplastic compounds we have found that four-membered, linear 5,11-dimethyl -5H- indolo[2,3-b]quinoline (DIMIQ) reveals cytostatic activity in vitro and moderate antitumor activity in vivo in mice melanoma B16 as well as leukemias L1210 and P388. Preliminary studies showed that DIMIQ stabilizes DNA-topoisomerase II complex. Some years later indolo[2,3-b]quinoline was found as an alkaloi...

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Literature Corpus work: 3ac589ac-9e99-5a0a-a2c8-f682bc819bb7
DOI: 10.7287/peerj.preprints.1669v1

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