Article
Design and Synthesis of Non-Covalent Imidazo[1,2-a]quinoxaline-Based Inhibitors of EGFR and Their Anti-Cancer Assessment.
Molecules (Basel, Switzerland) - 9 Mar 2021
Kumar Manvendra, Joshi Gaurav, Arora Sahil, Singh Tashvinder, Biswas Sajal, Sharma Nisha, Bhat Zahid Rafiq, Tikoo Kulbhushan, Singh Sandeep, Kumar Raj
Abstract excerpt
A series of 30 non-covalent imidazo[1,2-a]quinoxaline-based inhibitors of epidermal growth factor receptor (EGFR) were designed and synthesized. EGFR inhibitory assessment (against wild type) data of compounds revealed 6b, 7h, 7j, 9a and 9c as potent EGFRWT inhibitors with IC50 values of 211.22, 222.21, 193.18, 223.32 and 221.53 nM, respectively, which were comparable to erlotinib (221.03 nM), a positive control....
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