Article

The glioblastoma suppression effect of recombinant Newcastle disease virus harboring the PTEN gene delivered intravenously to a U87 MG PTEN mutant glioblastoma cell-bearing orthotropic mouse model

2023-03-24

Abstract excerpt

<title>Abstract</title> <p>Glioblastoma (GBM) is the most malignant brain tumor and is associated with a low survival and high recurrence rate. Deletions and mutations in phosphatase and tensin homolog (PTEN), a tumor suppressor gene, are associated with therapeutic resistance. In this study, we constructed a recombinant Newcastle disease virus (rNDV) overexpressing human PTEN (rNDV-PTEN) in GBM cells. PTEN overe...

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Literature Corpus work: 3a8ccb79-553d-559f-bf9b-f4b1c28f82ba
DOI: 10.21203/rs.3.rs-2676735/v1

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