Article

Contractility governs cardiomyocyte cell cycle activity

2025-08-20

Abstract excerpt

The heart’s rhythmic contractions keep blood flowing to deliver the oxygen and nutrients that sustain life, but this very strength may also explain why the heart has so little capacity to regenerate. Whereas embryonic and neonatal hearts can repair themselves, this ability is rapidly lost after birth as heart muscle cells (cardiomyocytes) exit the cell cycle. We tested whether the force-generating machinery of the...

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Literature Corpus work: 3a89112f-eca2-5573-b4fc-6eecb40a0c7f
DOI: 10.1101/2025.08.19.671096

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