Article

The pathobiology of <i>Mycobacterium abscessus</i> revealed through phenogenomic analysis

2021-10-18

Abstract excerpt

<h4>ABSTRACT</h4> The medical and scientific response to emerging pathogens is often severely hampered by ignorance of the genetic determinants of virulence, drug resistance, and clinical outcomes that could be used to identify therapeutic drug targets and forecast patient trajectories 1–5 . Taking the newly emergent multidrug-resistant bacteria Mycobacterium abscessus as an example 6 , we show that combining...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3a73ea57-acf1-599d-9763-3276c7544d7c
DOI: 10.1101/2021.10.18.464689

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The pathobiology of <i>Mycobacterium abscessus</i> revealed through phenogenomic analysisDOI 10.1101/2021.10.18.464689Read

Mycobacterium abscessus pathogenesis identified by phenogenomic analysesSemantic proximity Read

Transcriptional Regulator, Metabolic, and Pilus Biosynthesis Genes as Candidate Virulence Markers in High-Virulence <i>Mycobacterium abscessus</i>Semantic proximity Read

GplR1, an unusual TetR-like transcription factor in <i>Mycobacterium abscessus</i> , controls the production of cell wall glycopeptidolipids, colony morphology, and virulenceSemantic proximity Read

Lipid metabolic pathways determine phage infectivity in <i>Mycobacterium abscessus</i>Semantic proximity Read

Lsr2, a pleiotropic regulator at the core of the infectious strategy of <i>Mycobacterium abscessus</i>Semantic proximity Read

Recent progress towards understanding genetic variation in the Mycobacterium abscessus complex.Semantic proximity Read

A multiplexed, target-based phenotypic screening platform using CRISPR interference in <i>Mycobacterium abscessus</i>Semantic proximity Read

A statistical genomics framework to trace bacterial genomic predictors of clinical outcomes in <i>Staphylococcus aureus</i> bacteraemiaSemantic proximity Read

Allelic diversity uncovers protein domains contributing to the emergence of antimicrobial resistanceSemantic proximity Read

Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysisSemantic proximity Read

Transcriptome remodeling contributes to epidemic disease caused by the human pathogen <i>Streptococcus pyogenes</i>Semantic proximity Read

Detecting, mapping, and suppressing the spread of a decade-long <i>Pseudomonas aeruginosa</i> nosocomial outbreak with genomicsSemantic proximity Read