Article

Aberrant STAT signaling drives T cell dysregulation in a targetable pediatric sepsis endotype

2024-06-11

Abstract excerpt

<h4>ABSTRACT</h4> Sepsis is a leading cause of morbidity and mortality in critically ill children, yet heterogeneity in immune responses complicates the development of targeted therapies. Although immune dysregulation is associated with poor outcomes in sepsis, it remains unclear which host immune factors contribute causally to sepsis morbidity and mortality. To address this gap, we integrated deep immune phenotyp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3a375c77-84f4-53ed-b8d3-2eab655645d3
DOI: 10.1101/2024.06.11.24308709

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aberrant STAT signaling drives T cell dysregulation in a targetable pediatric sepsis endotypeDOI 10.1101/2024.06.11.24308709Read

Immunology of severe febrile illness in children in the COVID-19 eraSemantic proximity Read

Whole Blood Transcriptomics Identifies Subclasses of Pediatric Septic ShockSemantic proximity Read

Whole blood transcriptomics identifies subclasses of pediatric septic shockSemantic proximity Read

The landscape of immune dysregulation in pediatric sepsis at a single-cell resolutionSemantic proximity Read

Comparative immuno-biology at clinical recognition of early multiple organ dysfunction syndrome in pediatric and adult patients using single-cell transcriptomicsSemantic proximity Read

International multi-cohort analysis identifies novel framework for quantifying immune dysregulation in critical illness: results of the SUBSPACE consortiumSemantic proximity Read

Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severitySemantic proximity Read

Data driven analysis reveals shared transcriptome response and immune cell composition across aetiologies of critical illnessSemantic proximity Read

Deep Immune Profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19Semantic proximity Read

Pediatric Sepsis: Evolving Subphenotypes, Overlap Syndromes, and the Path to Precision Therapies.Semantic proximity Read

Deep immune profiling uncovers novel associations with clinical phenotypes of Multisystem Inflammatory Syndrome in Children (MIS-C)Semantic proximity Read

Machine learning driven identification of gene-expression signatures correlated with multiple organ dysfunction trajectories and complex sub-endotypes of pediatric septic shockSemantic proximity Read