Copper modulates sex-specific fructose hepatoxicity in nonalcoholic fatty liver disease (NALFD) Wistar rat models.

doi:10.1016/j.jnutbio.2019.108316

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Article

Copper modulates sex-specific fructose hepatoxicity in nonalcoholic fatty liver disease (NALFD) Wistar rat models.

The Journal of nutritional biochemistry - 1 Apr 2020

Morrell Austin, Tripet Brian P, Eilers Brian J, Tegman Megan, Thompson Damon, Copié Valérie, Burkhead Jason L

Abstract excerpt

This study aimed to characterize the impact of dietary copper on the biochemical and hepatic metabolite changes associated with fructose toxicity in a Wistar rat model of fructose-induced liver disease. Twenty-four male and 24 female, 6-week-old, Wister rats were separated into four experimental dietary treatment groups (6 males and 6 females per group), as follows: (1) a control diet: containing no fructose with...

Topics

Animals
Copper
Copper-Transporting ATPases
Diet
Disease Models, Animal
Disease Progression
Female
Fructose
Liver
Magnetic Resonance Spectroscopy
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Metabolomics

Multivariate Analysis

Non-alcoholic Fatty Liver Disease

Phenotype

Principal Component Analysis

Rats

Rats, Wistar

Source

Open in PubMed Open full text

Identifiers

PMID: 31986483
DOI: 10.1016/j.jnutbio.2019.108316
PMCID: PMC7078045

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