Article

A conserved regulation of cell expansion underlies notochord mechanics, spine morphogenesis, and endochondral bone lengthening

2024-08-13

Abstract excerpt

<h4>SUMMARY</h4> Cell size is a key contributor to tissue morphogenesis 1 . As a notable example, growth plate hypertrophic chondrocytes use cellular biogenesis and disproportionate fluid uptake to expand 10-20 times in size to drive lengthening of endochondral bone 2,3 . Similarly, notochordal cells expand to one of the largest cell types in the developing embryo to drive axial extension 4–6 . In zebrafish, t...

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Literature Corpus work: 39b76548-f39c-588e-8a12-33b6f1b682f1
DOI: 10.1101/2024.08.12.607640

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